ph2rand provides functions to assist with the design of randomized comparative phase II oncology trials that assume their primary outcome variable is Bernoulli distributed. Specifically, support is provided to (a) perform a sample size calculation when using one of several published designs, (b) evaluate the operating characteristics of a given design (both analytically and via simulation), and (c) produce informative plots.
You can install the latest development version of ph2rand from Github with:
devtools::install_github("mjg211/ph2rand")
An introductory example of how to make use of the package's core functionality can be found here. For further help, please see the package vignettes or email michael.grayling@newcastle.ac.uk.
Currently, the following functions are available (exported)
des_one_stage: Determine a one-stage randomized
comparative phase II oncology trial design, assuming a Bernoulli primary
outcome variable.
des_two_stage: Determine a two-stage randomized
comparative phase II oncology trial design, assuming a Bernoulli primary
outcome variable.
opchar: Evaluate the operating characteristics
(analytically) of a randomized comparative phase II oncology trial design
that assumes a Bernoulli primary outcome variable.
plot.ph2rand_des: Plot the operating characteristics of a
randomized comparative phase II oncology trial design that assumes a
Bernoulli primary outcome variable.
plot.ph2rand_pmf: Plot the probability mass function of a
randomized comparative phase II oncology trial design that assumes a
Bernoulli primary outcome variable.
plot.ph2rand_terminal: Plot the terminal points of a
randomized comparative phase II oncology trial design that assumes a
Bernoulli primary outcome variable.
pmf: Find the probability mass function of a randomized
comparative phase II oncology trial design that assumes a Bernoulli primary
outcome variable.
sim: Evaluate the operating characteristics (via
simulation) of a randomized comparative phase II oncology trial design
that assumes a Bernoulli primary outcome variable.
summary.ph2rand_des: Display a summary of a randomized
comparative phase II oncology trial design that assumes a Bernoulli primary
outcome variable.
terminal: Find the terminal points of a randomized
comparative phase II oncology trial design that assumes a Bernoulli primary
outcome variable.
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Litwin S, Basickes S, Ross EA (2017) Two-sample binary phase 2 trials with low type I error and low sample size. Stat Med 36(9):1383--94. DOI: doi: 10.1002/sim.7226 . PMID: 28118686.
Shan G, Ma C, Hutson AD, Wilding GE (2013) Randomized two-stage phase II clinical trial designs based on Barnard's exact test. J Biopharm Stat 23(5):1081--90. DOI: doi: 10.1080/10543406.2013.813525 . PMID: 23957517.