sim_ss_pois() determines the operating characteristics of a specified single-stage multi-arm clinical trial design assuming the primary outcome is Poisson distributed, for given values of the true treatment effects, using simulation.

sim_ss_pois(
  des = des_ss_pois(integer = TRUE),
  lambda,
  replicates = 1e+05,
  summary = FALSE
)

Arguments

des

A list of class "multiarm_des_ss_pois", as returned by build_ss_pois or des_ss_pois (i.e., a single-stage multi-arm clinical trial design for a Poisson distributed outcome). Note: The sample sizes in all arms must be whole numbers. Defaults to des_ss_pois(integer = TRUE).

lambda

A matrix whose rows indicate values of λ at which to evaluate the operating characteristics. Defaults internally to the global null, global alternative, and each of the least favourable configurations if unspecified.

replicates

A numeric indicating the number of replicate simulations to use for each value of λ. Defaults to 1e5.

summary

A logical variable indicating whether a summary of the function's progress should be printed to the console. Defaults to FALSE.

Value

A list containing the following elements

  • A tibble in the slot $sim giving the estimated operating characteristics.

  • Each of the input variables.

See also

Examples

if (FALSE) { # The estimated operating characteristics for the default parameters sim <- sim_ss_pois() # An A-optimal design, specifying tau explicitly des_A <- des_ss_pois(ratio = "A", integer = T) sim_A <- sim_ss_pois(des_A, rbind(c(0, 0), c(0.5, 0.5), c(0.5, 0), c(0, 0.5))) }